A disease is a medical condition where the normal functioning of our body is affected, which results in particular signs and symptoms. Understanding the molecular mechanisms underlying the onset and progression of diseases is a fundamental step to arrive to effective and efficient therapeutic intervention and drug treatments. The rapid advances in systems biology and biotechnology have equipped scientists with promising tools to fight diseases.

2022 iGEM WUR ↗ from the Netherlands was awarded a gold medal for developing a probiotic bacteria that can sense colorectal cancer at an early stage.

This Research Topic was open for iGEM Competition participants and it was intended as an avenue where student iGEM competing teams can present their work to the broader scientific community in the form of a peer-reviewed paper.

We were interested in original research articles, systematic reviews, and methods that tackle various diseases and use systems/synthetic biology principles and bioengineering methods. New engineering methods were encouraged. We welcomed articles that discussed diagnostics and therapeutic developments for disease. Original research and new methods articles were also a main focus because it has the scope to lead the field into new and exciting directions.

Our expert Editors guided authors through the peer review process with support also provided by Frontiers. The manuscripts followed all the guidelines ↗ given on the journal website for the specific article type.

Biology is a broad science so it has many definitions, theories and explanations about the mechanisms that sustain life. Synthetic biology utilizes biological principles to create what can be seen as a technology. Examples of the interdisciplinary technology are based on many types of self-organization (self-activity, self-assembly, self-replication, autonomy) by using an engineering approach to biology. BioBrick and biocircuit technologies in synthetic biology are important because they increase the capacity of testing, designing and synthesizing that can be done in biological systems and beyond.

By developing new technologies we can improve the most important areas for the progress of synthetic biology: digital biology, the problem of sameness in biology, pattern recognition, and the construction of artificial proteins. Biotechnology and synthetic biology have been advancing like never before. Numerous great tools are used in research that allows fields to progress faster than ever, but we still have a long way to go.

This Research Topic is open for iGEM Competition participants and our expert Editors will guide authors through the peer review process with support also provided by Frontiers.

We were interested in original research articles, systematic reviews, and methods that tackle the field of biotechnology. Technology in synthetic biology is very useful for applications in medicine, climate change, energy, and beyond. We suggested thinking about articles titles with general themes like: synthetic biology as technology, synthetic biology as part of Biotechnology, biopatterning technology for the development of biotechnology, What is Biopatterning recognition? What is biopatterning technology? Which are the main problems for the development of synthetic biology? The manuscripts followed all the rules guidelines ↗ given in the journal website for this type of article, and it can be done in many different formats.

Biomanufacturing is the use of biological systems, such as microorganisms, animal cells, or plant cells, to produce valuable products such as vaccines, therapeutic proteins, biofuels, and enzymes. It involves the manipulation and engineering of living organisms to produce specific compounds or materials, using advanced biotechnology techniques.

Biomanufacturing has the potential to provide more sustainable and eco-friendly alternatives to traditional manufacturing methods, as it can use renewable resources and reduce waste and energy consumption. Biomanufacturing in the field of systems microbiology is rapidly expanding, with new technologies and applications emerging all the time and the industrial scale up needed to match with manufacturing and commercial processes requires time and investment for success. If completed correctly though, it has significant implications for medicine, energy, agriculture, and many other industries.

This Research Topic was open for iGEM Competition participants and our expert Editors guided authors through the peer review process with support also provided by Frontiers.

We were interested in original research articles, systematic reviews, and methods that tackle various biomanufacturing problems and use synthetic biology principles and bioengineering methods. New engineering methods were encouraged. We prefered the articles to utilize synthetic biology. Original research and new methods articles were a main focus because it has the scope to lead the field into new and exciting directions. The manuscripts followed all the rules guidelines ↗ given in the journal website for this type of article, and it can be done in many different formats.

Bioremediation is a process that uses living organisms, such as bacteria, fungi, or plants, to clean up environmental pollutants. These organisms can break down or transform harmful substances, such as oil spills, pesticides, and heavy metals, into less toxic or non-toxic compounds. Bioremediation can be a cost-effective and environmentally friendly alternative to traditional methods of cleanup, such as incineration or excavation.

However, the effectiveness of bioremediation depends on several factors, including the type of pollutant, the environmental conditions, and the ability of the chosen organism to degrade the pollutant. Bioremediation has been used successfully in a variety of settings, including oil spills, contaminated soil, and groundwater. The complexity involved however in predicting and controlling such events would benefit greatly from a systems biology frame and the use of systems biology tools, such as metabolic networks alongside computational tools.

This Research Topic was open for iGEM Competition participants and our expert Editors guided authors through the peer review process with support also provided by Frontiers.

We were interested in original research articles, systematic reviews, and methods that tackle various bioremediation, environment, agriculture and food problems and use synthetic biology principles and bioengineering methods. New engineering methods were encouraged. We prefered the articles to utilize synthetic biology. Original research and new methods articles were a main focus because it has the scope to lead the field into new and exciting directions. The manuscripts followed all the rules guidelines ↗ given in the journal website for this type of article, and it can be done in many different formats.