The urgency for sustainable solutions to escalating global environmental challenges is at an all-time high. In response, the application of Systems Biology and Synthetic Biology have emerged as a promising avenue, offering innovative approaches to address and potentially reverse these pressing issues.

Our objective is to showcase the novel strategies in which researchers utilize Systems Biology and Synthetic Biology as effective tools for sustainable development to unearth studies outlining bioengineered systems or processes for renewable energy production, biofuel production, or advances that contribute to energy efficiency. This includes, but is not limited to: Ecosystem Conservation, Climate Crisis, Bioremediation and Environment.

This Research Topic encourages submissions from the iGEM community and researchers around the globe who work in areas intersecting Systems Biology, Synthetic Biology and Sustainability. Investigators who pioneer strategies utilizing these biological techniques to address environmental challenges and those who work on enhancing the field's potential to enable sustainable development are particularly encouraged to submit their research. Through this topic, it is our aim to foster meaningful global conversations on how Systems Biology and Synthetic Biology can influence our efforts towards sustainable actions. We invite researchers to share their findings in the form of original research, reviews, perspectives, technology and code, or novel methods and/or their novel applications.

Please note manuscripts that are purely synthetic without a systems approach (i.e. at multiple levels/scales/time points or using multiple methods such as multi-omics) will be considered in our newly launched Frontiers in Synthetic Biology. Please see our 2023 iGEM collection ↗ for an idea of systems level papers.

Meeting the challenge of feeding a growing global population sustainably amidst increasing extreme weather events requires innovative solutions. Systems Biology and Synthetic Biology offer a promising avenue to revolutionize agriculture. By engineering biological systems, we can enhance crop resilience, nutrient uptake, and yield under adverse conditions. Additionally, Systems Biology and Synthetic Biology enable precise manufacturing of valuable molecules and high-value compounds, while also facilitating micro-scale production processes that minimize waste. Responsible biotechnological interventions can further reduce food waste and synthesize essential nutrients without harming the environment. Integrating both Systems Biology and Synthetic biology into agriculture holds the potential to create a sustainable food system that meets the world's nutritional needs while preserving our planet for future generations.

Our objective is to spotlight the multifaceted applications of Systems Biology and Synthetic Biology as potent tools for advanced agriculture and food systems. This includes, but is not limited to: Food & Nutrition, Biomanufacturing in Agriculture, and Agriculture.

This Research Topic encourages submissions from the iGEM community and researchers around the globe who work in areas intersecting Systems Biology, Synthetic Biology and advanced agriculture and food systems. Investigators who pioneer the development of potent tools integrating these fields with a focus on sustainable food systems are particularly encouraged to submit their research. We invite researchers to share their findings in the form of original research, reviews, perspectives, technology and code, or novel methods and/or their novel applications.

Please note manuscripts that are purely synthetic without a systems approach (i.e. at multiple levels/scales/time points or using multiple methods such as multi-omics) will be considered in our newly launched Frontiers in Synthetic Biology. Please see our 2023 iGEM collection ↗ for an idea of systems level papers.

Systems Biology emphasizes the interconnectedness and interactions of various biological components within living organisms. Integrating these principles into biomedical research and healthcare to advance diagnostic and therapeutic capabilities offers insights into complex biological processes, networks, and dynamics. This addresses critical challenges in healthcare delivery, focusing on the development of faster, cheaper, and more effective diagnostic techniques to improve global access to medical treatment, enhance preventive healthcare, public health, and epidemiology. Existing technologies can be improved, and accessibility to novel therapies can be addressed, thereby bolstering a diverse array of health and medical challenges. Technologies like biological standard parts and biocircuitry expand testing, designing, and synthesizing capacities within biological systems, driving advancements in digital biology, pattern recognition, and artificial protein construction.

Our objective is to spotlight the multifaceted applications of Systems Biology as a potent tool for biomedical innovations and healthcare. This includes, but is not limited to: Diagnostics, Therapeutics, Foundational Advances in Medical Research, and Biomanufacturing in Pharmaceuticals and Medical Devices.

This Research Topic encourages submissions from the iGEM community and researchers around the globe who work in areas intersecting Systems Biology, Synthetic Biology and Biomedical innovations and healthcare. Investigators who pioneer the development of potent technologies integrating these fields with a focus on diagnostics, therapeutics, foundational advances and biomanufacturing for pharmaceuticals are particularly encouraged to submit their research. We invite researchers to share their findings in the form of original research, reviews, perspectives, technology and code, or novel methods and/or their novel applications.

Please note manuscripts that are purely synthetic without a systems approach (i.e. at multiple levels/scales/time points or using multiple methods such as multi-omics) will be transferred for consideration in Frontiers in Synthetic Biology and will not form part of the iGEM 2024 collection. Please see our 2023 iGEM collection ↗ for an idea of systems level papers.

Technological advancement occurs when technologies or applied sciences become more precise, accurate, efficient, or more powerful or capable. Scientific and technological advancements have made many important changes throughout history, some better than others.

Our objective is to spotlight the multifaceted applications of Systems Biology, Synthetic Biology, and Bioinformatics at the intersection of technological advancements to address several challenges. This includes, but is not limited to: Computational Biology, Software, and AI, Data Visualization, and Space Exploration.

This Research Topic encourages submissions from the iGEM community and researchers around the globe who work in areas intersecting Systems Biology, Synthetic Biology, AI, software, Bioinformatics, and technological advancements. Investigators who pioneer the development of potent technologies integrating these fields are particularly encouraged to submit their research. We invite researchers to share their findings in the form of original research, reviews, perspectives, technology and code, or methods.

Please note manuscripts that intersect fields can be considered for Frontiers in Systems Biology, manuscripts that allow for the visualization of complex biological data will be considered for Frontiers in Bioinformatics, and manuscripts that are a purely synthetic without a systems or integrative approach (i.e. at multiple levels/scales/time points or using multiple methods such as multi-omics, or intersecting multiple fields) will be considered in our newly launched Frontiers in Synthetic Biology. Those Please see our 2023 iGEM collection ↗ for an idea of systems level papers.